2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
- Product Name
- 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
- CAS No.
- 478482-75-6
- Chemical Name
- 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
- Synonyms
- TIBPO;GSK3β Inhibitor II;GSK-3 INHIBITOR II;GSK3.beta. Inhibitor II;GLYCOGEN SYNTHASE KINASE-3 INHIBITOR II;GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem;2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE;2-((3-Iodobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole;4-[5-[[(3-Iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine;2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
- CBNumber
- CB2201711
- Molecular Formula
- C14H10IN3OS
- Formula Weight
- 395.22
- MOL File
- Mol file
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Property
- Boiling point:
- 532.6±60.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- -20C
- solubility
- ≤3mg/ml in DMSO;10mg/ml in dimethyl formamide
- form
- Yellow solid
- pka
- 0.97±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 361541
- Product name
- GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem
- Packaging
- 5mg
- Price
- $141
- Updated
- 2021/12/16
- Product number
- 19077
- Product name
- GSK3β Inhibitor II
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 19077
- Product name
- GSK3β Inhibitor II
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- C4599
- Product name
- GSK-3βInhibitorII
- Packaging
- 10mg
- Price
- $198
- Updated
- 2021/12/16
- Product number
- 9903CP
- Product name
- GSK-3InhibitorII
- Packaging
- 5mg
- Price
- $201
- Updated
- 2021/12/16
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Chemical Properties,Usage,Production
Definition
ChEBI: 2-[(3-iodophenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole is an aryl sulfide.
Biological Activity
gsk-3β inhibitor ii is a gsk-3β inhibitor.glycogen synthase kinase-3 (gsk-3), a protein-serine kinase, is implicated in the hormonal control of various regulatory proteins. a number of substrates have been identified, which implicates gsk-3 in the regulation of several physiological processes. moreover, it has been reported that compounds that specifically inhibit gsk-3 activity may be useful in the treatment of diabetes.
in vitro
in a previous study, by using a virtual screening strategy based on a methodology derived from the cats molecular descriptor, a novel compound class including gsk-3β inhibitor ii with inhibitory activity against the gsk-3 enzyme was identified via scaffold hopping. gsk-3β inhibitor ii was found to be a potent inhibitor of gsk-3β with the ic50 value of 390 nm. however, gsk-3β inhibitor ii was not able to inhibit another gsk-3 isoform, gsk-3α [1]. another study found that gsk-3β inhibitor ii could block the functional regulation of p53 through inhibiting gsk-3β, decreasing mdm2 levels, and modulating mitochondrial p53 apoptotic signaling [2].
IC 50
390 nm for gsk-3β
References
[1] naerum, l. ,nrskov-lauritsen, l. and olesen, p.h. scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. bioorg.med.chem.lett. 12(11), 1525-1528 (2002).
[2] watcharasit, p. ,bijur, g.n.,song, l., et al. glycogen synthase kinase-3beta (gsk3beta) binds to and promotes the actions of p53. j.biol.chem. 278(49), 49972-48879 (2003).
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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